TY - CHAP
T1 - Viral and Nonviral Drug Delivery Systems for Medical Health Care
T2 - An Overview
AU - Ghosh, Ananya
AU - Gouda, Suahanto
AU - Kerry, Rout George
AU - Das, Gitishree
AU - Patra, Jayanta Kumar
N1 - Publisher Copyright:
© 2020, Springer Nature Switzerland AG.
PY - 2020
Y1 - 2020
N2 - The twentieth century had witnessed a significant revolution in the field of therapeutic medicines and drug delivery system. Numerous compounds with physiological significance including hormones, probiotics, provitamins, and other biological molecules were synthesized and discovered through modern tools and techniques. In this phase, special interest was also focused on virus and other pathogenic microbes as potential vector for conveyance of these compounds to their desired destination. Viruses such as retroviral vectors, adenoviral vectors and cationic lipid-based retroviral vectors, and adenoviral vectors and cationic lipid-based upon mutated and when used with appropriate precision have been successful against muscular, cardiovascular, ophthalmologic, hematologic, and infectious diseases. However, incidences of revert mutation and the gain of function by virulent genes have hindered the applications of viruses severely. The introduction of non-viral vector systems was able to overcome this limitation up to a great extent. Non-viral delivery cascades include a wide range of transport mechanisms ranging from micro- and nano-sized particles to complex polymeric structures. While various factors are required to be taken into account for the selection of vectors like compatibility, pathogenicity to humans, and the availability of procedures for large-scale production, recent advances in vector engineering and its delivery, along with its biosafety features and immunotherapeutic roles, raise new hopes for viruses to be used as vector again. In this chapter, we have an elaborate discussion of various viral and non-viral delivery systems, what they are, their applications, as well as the cutting-edge research, which are being conducted on them to augment the current medicinal approaches.
AB - The twentieth century had witnessed a significant revolution in the field of therapeutic medicines and drug delivery system. Numerous compounds with physiological significance including hormones, probiotics, provitamins, and other biological molecules were synthesized and discovered through modern tools and techniques. In this phase, special interest was also focused on virus and other pathogenic microbes as potential vector for conveyance of these compounds to their desired destination. Viruses such as retroviral vectors, adenoviral vectors and cationic lipid-based retroviral vectors, and adenoviral vectors and cationic lipid-based upon mutated and when used with appropriate precision have been successful against muscular, cardiovascular, ophthalmologic, hematologic, and infectious diseases. However, incidences of revert mutation and the gain of function by virulent genes have hindered the applications of viruses severely. The introduction of non-viral vector systems was able to overcome this limitation up to a great extent. Non-viral delivery cascades include a wide range of transport mechanisms ranging from micro- and nano-sized particles to complex polymeric structures. While various factors are required to be taken into account for the selection of vectors like compatibility, pathogenicity to humans, and the availability of procedures for large-scale production, recent advances in vector engineering and its delivery, along with its biosafety features and immunotherapeutic roles, raise new hopes for viruses to be used as vector again. In this chapter, we have an elaborate discussion of various viral and non-viral delivery systems, what they are, their applications, as well as the cutting-edge research, which are being conducted on them to augment the current medicinal approaches.
KW - Nanotechnology
KW - Recombinant protein technology
KW - Therapeutics
KW - Viral delivery system
UR - http://www.scopus.com/inward/record.url?scp=85102127786&partnerID=8YFLogxK
U2 - 10.1007/978-3-030-39246-8_2
DO - 10.1007/978-3-030-39246-8_2
M3 - Chapter
AN - SCOPUS:85102127786
T3 - Nanotechnology in the Life Sciences
SP - 21
EP - 41
BT - Nanotechnology in the Life Sciences
PB - Springer Science and Business Media B.V.
ER -