Virus-like nanoparticles as a theranostic platform for cancer

Kyeong Rok Kim, Ae Sol Lee, Su Min Kim, Hye Ryoung Heo, Chang Sup Kim

Research output: Contribution to journalReview articlepeer-review

21 Scopus citations

Abstract

Virus-like nanoparticles (VLPs) are natural polymer-based nanomaterials that mimic viral structures through the hierarchical assembly of viral coat proteins, while lacking viral genomes. VLPs have received enormous attention in a wide range of nanotechnology-based medical diagnostics and therapies, including cancer therapy, imaging, and theranostics. VLPs are biocompatible and biodegradable and have a uniform structure and controllable assembly. They can encapsulate a wide range of therapeutic and diagnostic agents, and can be genetically or chemically modified. These properties have led to sophisticated multifunctional theranostic platforms. This article reviews the current progress in developing and applying engineered VLPs for molecular imaging, drug delivery, and multifunctional theranostics in cancer research.

Original languageEnglish
Article number1106767
JournalFrontiers in Bioengineering and Biotechnology
Volume10
DOIs
StatePublished - 12 Jan 2023

Keywords

  • bio-imaging
  • cancer
  • drug delivery
  • theragnosis
  • virus-like particle

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