Wound healing evaluation of benzalkonium chloride-loaded hydrocolloid in the wound infection model

Jeong Hwan Kim; Sung Giu Jin; Sae Kwang Ku; Doo Hyun Nam; Young Taek Sohn; Dong Sung Ryu; Eui Seon Do; Sun Woo Jang; Mi Woon Son; Chul Soon Yong; Han Gon Choi; Jong Oh Kim

doi:10.1007/s40005-012-0043-2

Wound healing evaluation of benzalkonium chloride-loaded hydrocolloid in the wound infection model

Jeong Hwan Kim
, Sung Giu Jin
, Sae Kwang Ku
, Doo Hyun Nam
, Young Taek Sohn
, Dong Sung Ryu
, Eui Seon Do
, Sun Woo Jang
, Mi Woon Son
, Chul Soon Yong
, Han Gon Choi
, Jong Oh Kim

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

An adequate environment for wound healing improves cell proliferation and cell activity, rearranges fibroblasts, and suppresses the multiplication of bacteria. The aim of this study was to evaluate the wound-healing effects of a semi-occlusive hydrocolloid wound dressing (HWD) containing a topical antiseptic drug, benzalkonium chloride (BKC) in an infectious wound model. In vivo wound-healing profiles in rats exhibited that BKC-loaded HWD successfully promoted epithelialization rate, compared with gauze control or HWD without BKC. Furthermore, the significant decrease in desquamated epithelial regions, numbers of microvessels and inflammatory cells infiltrated in granulation tissues and granulation tissue areas were observed in the histopathological and histomorphometrical profiles of BKC-loaded HWD. In conclusion, these results suggest that BKC-loaded HWD facilitates wound healing and re-epithelization, and has promising effects for the treatment of infected wounds, as compared to HWD without BKC.

Original language	English
Pages (from-to)	327-333
Number of pages	7
Journal	Journal of Pharmaceutical Investigation
Volume	42
Issue number	6
DOIs	https://doi.org/10.1007/s40005-012-0043-2
State	Published - Dec 2012

Keywords

Benzalkonium chloride
Hydrocolloid
Wound dressing
Wound healing

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10.1007/s40005-012-0043-2

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title = "Wound healing evaluation of benzalkonium chloride-loaded hydrocolloid in the wound infection model",

abstract = "An adequate environment for wound healing improves cell proliferation and cell activity, rearranges fibroblasts, and suppresses the multiplication of bacteria. The aim of this study was to evaluate the wound-healing effects of a semi-occlusive hydrocolloid wound dressing (HWD) containing a topical antiseptic drug, benzalkonium chloride (BKC) in an infectious wound model. In vivo wound-healing profiles in rats exhibited that BKC-loaded HWD successfully promoted epithelialization rate, compared with gauze control or HWD without BKC. Furthermore, the significant decrease in desquamated epithelial regions, numbers of microvessels and inflammatory cells infiltrated in granulation tissues and granulation tissue areas were observed in the histopathological and histomorphometrical profiles of BKC-loaded HWD. In conclusion, these results suggest that BKC-loaded HWD facilitates wound healing and re-epithelization, and has promising effects for the treatment of infected wounds, as compared to HWD without BKC.",

keywords = "Benzalkonium chloride, Hydrocolloid, Wound dressing, Wound healing",

author = "Kim, \{Jeong Hwan\} and Jin, \{Sung Giu\} and Ku, \{Sae Kwang\} and Nam, \{Doo Hyun\} and Sohn, \{Young Taek\} and Ryu, \{Dong Sung\} and Do, \{Eui Seon\} and Jang, \{Sun Woo\} and Son, \{Mi Woon\} and Yong, \{Chul Soon\} and Choi, \{Han Gon\} and Kim, \{Jong Oh\}",

year = "2012",

month = dec,

doi = "10.1007/s40005-012-0043-2",

language = "English",

volume = "42",

pages = "327--333",

journal = "Journal of Pharmaceutical Investigation",

issn = "2093-5552",

publisher = "Springer",

number = "6",

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T1 - Wound healing evaluation of benzalkonium chloride-loaded hydrocolloid in the wound infection model

AU - Kim, Jeong Hwan

AU - Jin, Sung Giu

AU - Ku, Sae Kwang

AU - Nam, Doo Hyun

AU - Sohn, Young Taek

AU - Ryu, Dong Sung

AU - Do, Eui Seon

AU - Jang, Sun Woo

AU - Son, Mi Woon

AU - Yong, Chul Soon

AU - Choi, Han Gon

AU - Kim, Jong Oh

PY - 2012/12

Y1 - 2012/12

N2 - An adequate environment for wound healing improves cell proliferation and cell activity, rearranges fibroblasts, and suppresses the multiplication of bacteria. The aim of this study was to evaluate the wound-healing effects of a semi-occlusive hydrocolloid wound dressing (HWD) containing a topical antiseptic drug, benzalkonium chloride (BKC) in an infectious wound model. In vivo wound-healing profiles in rats exhibited that BKC-loaded HWD successfully promoted epithelialization rate, compared with gauze control or HWD without BKC. Furthermore, the significant decrease in desquamated epithelial regions, numbers of microvessels and inflammatory cells infiltrated in granulation tissues and granulation tissue areas were observed in the histopathological and histomorphometrical profiles of BKC-loaded HWD. In conclusion, these results suggest that BKC-loaded HWD facilitates wound healing and re-epithelization, and has promising effects for the treatment of infected wounds, as compared to HWD without BKC.

AB - An adequate environment for wound healing improves cell proliferation and cell activity, rearranges fibroblasts, and suppresses the multiplication of bacteria. The aim of this study was to evaluate the wound-healing effects of a semi-occlusive hydrocolloid wound dressing (HWD) containing a topical antiseptic drug, benzalkonium chloride (BKC) in an infectious wound model. In vivo wound-healing profiles in rats exhibited that BKC-loaded HWD successfully promoted epithelialization rate, compared with gauze control or HWD without BKC. Furthermore, the significant decrease in desquamated epithelial regions, numbers of microvessels and inflammatory cells infiltrated in granulation tissues and granulation tissue areas were observed in the histopathological and histomorphometrical profiles of BKC-loaded HWD. In conclusion, these results suggest that BKC-loaded HWD facilitates wound healing and re-epithelization, and has promising effects for the treatment of infected wounds, as compared to HWD without BKC.

KW - Benzalkonium chloride

KW - Hydrocolloid

KW - Wound dressing

KW - Wound healing

UR - https://www.scopus.com/pages/publications/84876542275

U2 - 10.1007/s40005-012-0043-2

DO - 10.1007/s40005-012-0043-2

M3 - Article

AN - SCOPUS:84876542275

SN - 2093-5552

VL - 42

SP - 327

EP - 333

JO - Journal of Pharmaceutical Investigation

JF - Journal of Pharmaceutical Investigation

IS - 6

ER -

Wound healing evaluation of benzalkonium chloride-loaded hydrocolloid in the wound infection model

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Keywords

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